History
Cardiovascular symptoms in pericardial
effusion can include the following:
Chest pain, pressure, discomfort -
Characteristically, pericardial pain may be relieved by sitting up and leaning
forward and is intensified by lying supine.
·
Light-headedness,
syncope
·
Palpitations
Respiratory symptoms can include the
following:
·
Cough
·
Dyspnea
·
Hoarseness
Neurologic symptoms of pericardial
effusion can include anxiety and confusion, while hiccoughs may occur as a
gastrointestinal (GI) symptom.
Signs and symptoms
Signs and symptoms of pericardial
effusion include the following:
Chest pain, pressure, discomfort
Light-headedness, syncope
Palpitations
Cough
Dyspnea
Hoarseness
Anxiety and confusion
Hiccoughs
See Clinical Presentation for more
detail.
Diagnosis
Examination findings in patients with
pericardial effusion include the following:
Classic Beck triad of pericardial
tamponade: Hypotension, muffled heart sounds, jugular venous distention
Pulsus paradoxus
Pericardial friction rub
Tachycardia
Hepatojugular reflux
Tachypnea
Decreased breath sounds
Ewart sign: Dullness to percussion
beneath the angle of left scapula
Hepatosplenomegaly
Weakened peripheral pulses, edema, and
cyanosis
Lab tests
The following laboratory studies may be
performed in patients with suspected pericardial effusion:
Electrolyte levels
CBC count with differential
Cardiac biomarker levels (eg, troponin,
CK-MB, LDH)
Tests for other markers of inflammation
(eg, ESR, CRP)
TSH level
Blood cultures
RF levels
Immunoglobulin complex tests
ANA tests
Complement levels
Pericardial fluid analysis
Early in the course of acute
pericarditis, the ECG typically displays diffuse ST elevation in association
with PR depression; the ST elevation is usually present in all leads except for
aVR, although in postmyocardial infarction pericarditis, the changes may be
more localized.
Specific tests for infectious diseases
or other conditions may also be warranted, based upon clinical suspicion, such
as the following:
Viral cultures
Tuberculin skin testing or
QuantiFERON-TB assay
Rickettsial antibodies
HIV serology
Adenosine deaminase levels
CEA levels
PCR
Imaging studies
Echocardiography is the imaging modality
of choice for the diagnosis of pericardial effusion and includes the following
techniques:
2-D echocardiography
M-mode echocardiography: Adjunct to 2-D
echocardiography
Doppler echocardiography
Transesophageal echocardiography
Intracardiac echocardiography
Other radiologic studies used in the
evaluation of pericardial effusion include the following:
Chest radiography
Chest CT Scanning and MRI: May be
superior to echocardiography in detecting loculated pericardial effusions
Procedures
Procedures that may be used in patients
with pericardial effusion include the following:
Diagnostic and/or therapeutic
pericardiocentesis
Diagnostic pericardioscopy
Placement of a pulmonary artery catheter
See Workup for more detail.
Management
Most acute idiopathic or viral
pericarditis occurrences are self-limited and respond to treatment with an
NSAID. Prednisone may be administered for severe inflammatory pericardial
effusions or when NSAID treatment has failed.
Autoimmune pericardial effusions may
respond to treatment with anti-inflammatory medications. In general, selection
of an agent depends on the severity of the patient's symptoms and the
tolerability and adverse-effect profiles of the medications.
Pharmacotherapy for pericardial effusion
includes use of the following agents, depending on the etiology:
NSAIDs (eg, indomethacin, ibuprofen,
naproxen, diclofenac, ketoprofen, aspirin)
Corticosteroids (eg, prednisone,
methylprednisolone, prednisolone)
Anti-inflammatory agents (eg,
colchicine)
Antibiotics (eg, vancomycin, ceftriaxone,
ciprofloxacin, isoniazid, rifampin, pyrazinamide, ethambutol)
Antineoplastic therapy (eg, systemic
chemotherapy, radiation)
Sclerosing agents (eg, tetracycline,
doxycycline, cisplatin, 5-fluorouracil)
Hemodynamic support for pericardial
effusion includes the following:
Hemodynamic monitoring with a balloon
flotation pulmonary artery catheter
IV fluid resuscitation
Surgical treatments for pericardial
effusion include the following:
Pericardiostomy
Pericardotomy
Thoracotomy
Sternotomy
Pericardiocentesis